Pharmacological, Nonpharmacological and Psychological Therapy Approaches in Management of Perinatal Depression


  • Nurten ÖZÇALKAP



Non-pharmacological Method, Pharmacological Method, Perinatal Depression, Psychological Treatment, Psychotherapy


Perinatal depression is a common mood disorder that greatly affects the mother and baby, and refers to major and minor maternal depression that occurs during pregnancy and/or during the first year after birth. There are empirically validated psychological treatments for perinatal depression. Interpersonal psychotherapy and cognitive-behavioral therapies, which are reported to be effective for women in the perinatal period between mild and severe depression, are known as psychological treatment approaches. Although pharmacological interventions are an effective treatment for depression, mothers often turn to non-pharmacological interventions by avoiding antidepressant medication due to concerns about breastfeeding or other potential side effects. Considering the possible effects and harms of perinatal depression, early detection of symptoms, risk assessment, creation of an individualized care plan, and initiation of the right treatment in the early period are important. The aim of this study is to compile pharmacological, nonpharmacological and psychological treatment approaches in the management of perinatal depression in the light of the literatüre.


ACOG Committee Opinion No. 757: Screening for Perinatal Depression. (2018). Obstetrics and gynecology, 132(5), e208–e212.

Aktar, E., Qu, J., Lawrence, P. J., Tollenaar, M. S., Elzinga, B. M., & Bögels, S. M. (2019). Fetal and Infant Outcomes in the Offspring of Parents With Perinatal Mental Disorders: Earliest Influences. Frontiers in psychiatry, 10, 391.

Altın, G.E. (2012). Perinatal depresyon tedavisinde kişilerarası terapi. Psikiyatride Güncel Yaklaşımlar-Current Approaches in Psychiatry, 4(2), 188-203

American College of Obstetricians and Gynecologists (ACOG). (2020). Physical Activity and Exercise During Pregnancy and the Postpartum Period. Obstet. Gynecol.

Andrade, L. H., Alonso, J., Mneimneh, Z., Wells, J. E., Al-Hamzawi, A., Borges, G., Bromet, E., Bruffaerts, R., de Girolamo, G., de Graaf, R., Florescu, S., Gureje, O., Hinkov, H. R., Hu, C., Huang, Y., Hwang, I., Jin, R., Karam, E. G., Kovess-Masfety, V., Levinson, D., … Kessler, R. C. (2014). Barriers to mental health treatment: results from the WHO World Mental Health surveys. Psychological medicine, 44(6), 1303–1317.

Azeredo, C. M., Santos, I. S., Barros, A. J. D., Barros, F. C., & Matijasevich, A. (2017). Maternal depression and bullying victimization among adolescents: Results from the 2004 Pelotas cohort study. Depression and anxiety, 34(10), 897–907.

Babbar, S., Parks-Savage, A. C., & Chauhan, S. P. (2012). Yoga during pregnancy: a review. American journal of perinatology, 29(6), 459–464.

Barker, L. C., Dennis, C. L., Hussain-Shamsy, N., Stewart, D. E., Grigoriadis, S., Metcalfe, K., Oberlander, T. F., Schram, C., Taylor, V. H., & Vigod, S. N. (2020). Decision-making about antidepressant medication use in pregnancy: a comparison between women making the decision in the preconception period versus in pregnancy. BMC psychiatry, 20(1), 54.

Battle, C. L., Salisbury, A. L., Schofield, C. A., & Ortiz-Hernandez, S. (2013). Perinatal antidepressant use: understanding women's preferences and concerns. Journal of psychiatric practice, 19(6), 443–453.

Battle, C. L., Uebelacker, L. A., Magee, S. R., Sutton, K. A., & Miller, I. W. (2015). Potential for prenatal yoga to serve as an intervention to treat depression during pregnancy. Women's health issues : official publication of the Jacobs Institute of Women's Health, 25(2), 134–141.

Bauer, A., Knapp, M., Matijasevich, A., Osório, A., & de Paula, C. S. (2022). The lifetime costs of perinatal depression and anxiety in Brazil. Journal of affective disorders, 319, 361–369.

Beck, A. T., & Haigh, E. A. (2014). Advances in cognitive theory and therapy: the generic cognitive model. Annual review of clinical psychology, 10, 1–24.

Bérard, A., Sheehy, O., Zhao, J. P., Chambers, C., Roth, M., Bozzo, P., Johnson, D., Kao, K., Lavigne, S., Wolfe, L., Quinn, D., Dieter, K., & MotherToBaby Collaborative Research Committee (2019). Impact of antidepressant use, discontinuation, and dosage modification on maternal depression during pregnancy. European neuropsychopharmacology: The journal of the European College of Neuropsychopharmacology, 29(7), 803–812.

Bian, C., Zhao, W. W., Yan, S. R., Chen, S. Y., Cheng, Y., & Zhang, Y. H. (2023). Effect of interpersonal psychotherapy on social functioning, overall functioning and negative emotions for depression: A meta-analysis. Journal of affective disorders, 320, 230–240.

Bledsoe, S. E., & Grote, N. K. (2006). Treating depression during pregnancy and the postpartum: a preliminary meta-analysis. Research on Social Work Practice, 16(2), 109-120. 16(2).

Bledsoe, S. E., & Grote, N. K. (2006). Treating depression during pregnancy and the postpartum: a preliminary meta-analysis. Research on Social Work Practice, 16(2), 109-120.

Bloch, M., Daly, R. C., & Rubinow, D. R. (2003). Endocrine factors in the etiology of postpartum depression. Comprehensive psychiatry, 44(3), 234–246.

Branquinho, M., Shakeel, N., Horsch, A., & Fonseca, A. (2022). Frontline health professionals' perinatal depression literacy: A systematic review. Midwifery, 111, 103365.

Brown, A. S., Gyllenberg, D., Malm, H., McKeague, I. W., Hinkka-Yli-Salomäki, S., Artama, M., Gissler, M., Cheslack-Postava, K., Weissman, M. M., Gingrich, J. A., & Sourander, A. (2016). Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring. JAMA psychiatry, 73(11), 1163–1170.

Bruning, A. H., Heller, H. M., Kieviet, N., Bakker, P. C., de Groot, C. J., Dolman, K. M., & Honig, A. (2015). Antidepressants during pregnancy and postpartum hemorrhage: a systematic review. European journal of obstetrics, gynecology, and reproductive biology, 189, 38–47.

Carter , T., Bastounis, A., Guo B., & Morrell, C.J. (2019). The effectiveness of exercise-based interventions for preventing or treating postpartum depression: a systematic review and meta-analysis. Arch Womens Ment Health, 22(1), 37-53. doi: 10.1007/s00737-018-0869-3.

Castelli, R. D., Quevedo, L.deÁ., Coelho, F. M., Lopez, M. A., da Silva, R. A., Böhm, D. M.,… Pinheiro, R. T. (2015). Cognitive and language performance in children is associated with maternal social anxiety disorder: A study of young mothers in southern Brazil. Early human development, 91(12), 707–711.

Chang, M. Y., Chen, C. H., & Huang, K. F. (2008). Effects of music therapy on psychological health of women during pregnancy. Journal of clinical nursing, 17(19), 2580–2587.

Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y.,….. Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet (London, England), 391(10128), 1357–1366.

Corwin, E. J., Murray-Kolb, L. E., & Beard, J. L. (2003). Low hemoglobin level is a risk factor for postpartum depression. The Journal of nutrition, 133(12), 4139–4142.

Cuijpers, P., Brännmark, J. G., & van Straten, A. (2008). Psychological treatment of postpartum depression: a meta-analysis. Journal of clinical psychology, 64(1), 103–118.

Dennis, C. L., & Dowswell, T. (2013). Psychosocial and psychological interventions for preventing postpartum depression. The Cochrane database of systematic reviews, (2), CD001134.

Dennis, C. L., & Hodnett, E. (2007). Psychosocial and psychological interventions for treating postpartum depression. The Cochrane database of systematic reviews, (4), CD006116.

Dennis, C. L., Grigoriadis, S., Zupancic, J., Kiss, A., & Ravitz, P. (2020). Telephone-based nurse-delivered interpersonal psychotherapy for postpartum depression: nationwide randomised controlled trial. The British journal of psychiatry: the journal of mental science, 216(4), 189–196.

Dipietro, L., Evenson, K. R., Bloodgood, B., Sprow, K., Troiano, R. P., Piercy, K. L., ….Powell, K. E. (2019). Benefits of Physical Activity during Pregnancy and Postpartum: An Umbrella Review. Medicine and science in sports and exercise, 51(6), 1292–1302.

Dørheim, S. K., Bjorvatn, B., & Eberhard-Gran, M. (2014). Can insomnia in pregnancy predict postpartum depression? A longitudinal, population-based study. PloS one, 9(4), e94674.

Eke, A. C., Saccone, G., & Berghella, V. (2016). Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and risk of preterm birth: a systematic review and meta-analysis. BJOG :an international journal of obstetrics and gynaecology, 123(12), 1900–1907.

Evans, J., Ingram, J., Law, R., Taylor, H., Johnson, D., Glynn, J.,…O'Mahen, H. (2021). Interpersonal counselling versus perinatal-specific cognitive behavioural therapy for women with depression during pregnancy offered in routine psychological treatment services: a phase II randomised trial. BMC psychiatry, 21(1), 504.

Field T. (2017). Prenatal anxiety effects: A review. Infant behavior & development, 49, 120–128.

Field, T., Deeds, O., Diego, M., Hernandez-Reif, M., Gauler, A., Sullivan, S., Wilson, D., & Nearing, G. (2009). Benefits of combining massage therapy with group interpersonal psychotherapy in prenatally depressed women. Journal of bodywork and movement therapies, 13(4), 297–303.

Field, T., Diego, M., & Hernandez-Reif, M. (2010). Prenatal depression effects and interventions: a review. Infant behavior & development, 33(4), 409–418.

Field, T., Diego, M., Hernandez-Reif, M., Medina, L., Delgado, J., & Hernandez, A. (2012). Yoga and massage therapy reduce prenatal depression and prematurity. Journal of bodywork and movement therapies, 16(2), 204–209.

Field, T., Hernandez-Reif, M., Diego, M., Schanberg, S., & Kuhn, C. (2005). Cortisol decreases and serotonin and dopamine increase following massage therapy. The International journal of neuroscience, 115(10), 1397–1413.

Fischer Fumeaux, C. J., Morisod Harari, M., Weisskopf, E., Eap, C. B., Epiney, M., Vial, Y., Csajka, C., Bickle Graz, M., & Panchaud, A. (2019). Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence - an update. Expert opinion on drug safety, 18(10), 949–963.

Fisher, J., Cabral de Mello, M., Patel, V., Rahman, A., Tran, T., Holton, S., & Holmes, W. (2012). Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bulletin of the World Health Organization, 90(2), 139G–149G.

Fitelson, E., Kim, S., Baker, A. S., & Leight, K. (2010). Treatment of postpartum depression: clinical, psychological and pharmacological options. International journal of women's health, 3, 1–14.

Fitelson, E., Kim, S., Baker, A. S., & Leight, K. (2010). Treatment of postpartum depression: clinical, psychological and pharmacological options. International journal of women's health, 3, 1–14.

Forsyth, J., Boath, E., Henshaw, C., & Brown, H. (2017). Exercise as an adjunct treatment for postpartum depression for women living in an inner city-A pilot study. Health care for women international, 38(6), 635–639.

Gaillard, A., Le Strat, Y., Mandelbrot, L., Keïta, H., & Dubertret, C. (2014). Predictors of postpartum depression: prospective study of 264 women followed during pregnancy and postpartum. Psychiatry research, 215(2), 341–346.

Ghaedrahmati, M., Kazemi, A., Kheirabadi, G., Ebrahimi, A., & Bahrami, M. (2017). Postpartum depression risk factors: A narrative review. Journal of education and health promotion, 6, 60.

Grech, J., Calleja, N., Grech, J. (2022). Pregnant women's awareness, knowledge, and attitudes about perinatal depression. Mental Health & Prevention, 26, 200238.

Grote, N. K., Bridge, J. A., Gavin, A. R., Melville, J. L., Iyengar, S., & Katon, W. J. (2010). A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Archives of general psychiatry, 67(10), 1012–1024.

Hazell Raine, K., Nath, S., Howard, L. M., Cockshaw, W., Boyce, P., Sawyer, E., & Thorpe, K. (2020). Associations between prenatal maternal mental health indices and mother-infant relationship quality 6 to 18 months' postpartum: A systematic review. Infant mental health journal, 41(1), 24–39.

He, L., Soh, K. L., Huang, F., Khaza'ai, H., Geok, S. K., Vorasiha, P., Chen, A., & Ma, J. (2023). The impact of physical activity intervention on perinatal depression: A systematic review and meta-analysis. Journal of affective disorders, 321, 304–319.

Helle, N., Barkmann, C., Bartz-Seel, J., Diehl, T., Ehrhardt, S., Hendel, A.,…..Bindt, C. (2015). Very low birth-weight as a risk factor for postpartum depression four to six weeks postbirth in mothers and fathers: Cross-sectional results from a controlled multicentre cohort study. Journal of affective disorders, 180, 154–161.

Houston, K. A., Kaimal, A. J., Nakagawa, S., Gregorich, S. E., Yee, L. M., & Kuppermann, M. (2015). Mode of delivery and postpartum depression: the role of patient preferences. American journal of obstetrics and gynecology, 212(2),229.e1–229.e2297.

Jacques, N., Mesenburg, M. A., Murray, J., Bertoldi, A. D., Domingues, M. R., Stein, A., & Silveira, M. F. (2021). Antenatal and Postnatal Maternal Depressive Symptoms and Trajectories and Child Hospitalization up to 24 Months of Life: Findings From the 2015 Pelotas (Brazil) Birth Cohort Study. The journal of pediatrics: X, 6, 100065.

Jennings, K. D., Ross, S., Popper, S., & Elmore, M. (1999). Thoughts of harming infants in depressed and nondepressed mothers. Journal of affective disorders, 54(1-2), 21-28.).

Jiang, H. Y., Xu, L. L., Li, Y. C., Deng, M., Peng, C. T., & Ruan, B. (2016). Antidepressant use during pregnancy and risk of postpartum hemorrhage: A systematic review and meta-analysis. Journal of psychiatric research, 83, 160–167.

Jiang, X., Li, H., Wang, D., Shan, L., Kang, Y., & Wang, F. (2022). Efficacy of nondrug interventions in perinatal depression: a meta-analysis. Psychiatry Research, 114916.

Karaçam, Z., & Ançel, G. (2009). Depression, anxiety and influencing factors in pregnancy: a study in a Turkish population. Midwifery, 25(4), 344–356.

Kendig, S., Keats, J. P., Hoffman, M. C., Kay, L. B., Miller, E. S., Moore Simas, T. A.,…Lemieux, L. A. (2017). Consensus Bundle on Maternal Mental Health: Perinatal Depression and Anxiety. Journal of obstetric, gynecologic, and neonatal nursing: JOGNN, 46(2), 272–281.

Kołomańska-Bogucka, D., & Mazur-Bialy, A. I. (2019). Physical Activity and the Occurrence of Postnatal Depression-A Systematic Review. Medicina (Kaunas, Lithuania), 55(9), 560.

Lee, D. T., Yip, A. S., Leung, T. Y., & Chung, T. K. (2000). Identifying women at risk of postnatal depression: prospective longitudinal study. Hong Kong medical journal = Xianggang yi xue za zhi, 6(4), 349–354.

Leigh, B., & Milgrom, J. (2008). Risk factors for antenatal depression, postnatal depression and parenting stress. BMC psychiatry, 8, 24.

Li, X., Laplante, D. P., Paquin, V., Lafortune, S., Elgbeili, G., King, S. (2022). Effectiveness of cognitive behavioral therapy for perinatal maternal depression, anxiety and stress: A systematic review and meta-analysis of randomized controlled trials. Clinical psychology review, 92, 102129.

Ludermir, A. B., Lewis, G., Valongueiro, S. A., de Araújo, T. V., & Araya, R. (2010). Violence against women by their intimate partner during pregnancy and postnatal depression: a prospective cohort study. Lancet (London, England), 376(9744), 903–910.

Lutkiewicz, K., Bieleninik, Ł., Cieślak, M., & Bidzan, M. (2020). Maternal-Infant Bonding and Its Relationships with Maternal Depressive Symptoms, Stress and Anxiety in the Early Postpartum Period in a Polish Sample. International journal of environmental research and public health, 17(15), 5427.

Markowitz, J. C., & Weissman, M. M. (2004). Interpersonal psychotherapy: principles and applications. World psychiatry: official journal of the World Psychiatric Association (WPA), 3(3), 136–139.

Maruyama, J. M., Santos, I. S., Munhoz, T. N., & Matijasevich, A. (2021). Maternal depression trajectories and offspring positive attributes and social aptitudes at early adolescence: 2004 Pelotas birth cohort. European child & adolescent psychiatry, 30(12), 1939–1948.

Matijasevich, A., Murray, J., Cooper, P. J., Anselmi, L., Barros, A. J., Barros, F. C., & Santos, I. S. (2015). Trajectories of maternal depression and offspring psychopathology at 6 years: 2004 Pelotas cohort study. Journal of affective disorders, 174, 424–431.

Melville, J. L., Reed, S. D., Russo, J., Croicu, C. A., Ludman, E., LaRocco-Cockburn, A., & Katon, W. (2014). Improving care for depression in obstetrics and gynecology: a randomized controlled trial. Obstetrics and gynecology, 123(6), 1237–1246.

Míguez, M. C., Pereira, B., & Figueiredo, B. (2017). Tobacco consumption and spontaneous quitting at the first trimester of pregnancy. Addictive behaviors, 64, 111–117.

Milgrom, J., Gemmill, A. W., Bilszta, J. L., Hayes, B., Barnett, B., Brooks, J.,….Buist, A. (2008). Antenatal risk factors for postnatal depression: a large prospective study. Journal of affective disorders, 108(1-2),147–157.

Molenaar, N. M., Bais, B., Lambregtse-van den Berg, M. P., Mulder, C. L., Howell, E. A., Fox, N. S.,…..& Kamperman, A. M. (2020). The international prevalence of antidepressant use before, during, and after pregnancy: A systematic review and meta-analysis of timing, type of prescriptions and geographical variability. Journal of affective disorders, 264, 82–89.

Muzik, M., & Borovska, S. (2010). Perinatal depression: implications for child mental health. Mental health in family medicine, 7(4), 239–247.

National Collaborating Centre for Mental Health (UK). (2007). Antenatal and Postnatal Mental Health: The NICE Guideline on Clinical Management and Service Guidance. British Psychological Society.

Naveen, G. H., Varambally, S., Thirthalli, J., Rao, M., Christopher, R., & Gangadhar, B. N. (2016). Serum cortisol and BDNF in patients with major depression-effect of yoga. International review of psychiatry (Abingdon, England), 28(3), 273–278.

Nörby, U., Forsberg, L., Wide, K., Sjörs, G., Winbladh, B., & Källén, K. (2016). Neonatal Morbidity After Maternal Use of Antidepressant Drugs During Pregnancy. Pediatrics, 138(5), e20160181.

O'Hara, M. W., & Wisner, K. L. (2014). Perinatal mental illness: definition, description and aetiology. Best practice & research. Clinical obstetrics & gynaecology, 28(1), 3–12.

O'Hara, M. W., Pearlstein, T., Stuart, S., Long, J. D., Mills, J. A., & Zlotnick, C. (2019). A placebo controlled treatment trial of sertraline and interpersonal psychotherapy for postpartum depression. Journal of affective disorders, 245, 524–532.

Oswalt, K. L., Biasini, F. J., Wilson, L. L., & Mrug, S. (2009). Outcomes of a massage intervention on teen mothers: a pilot study. Pediatric nursing, 35(5), 284–317.

Özcan, N. K., Boyacıoğlu, N. E., & Dinç, H. (2017). Postpartum Depression Prevalence and Risk Factors in Turkey: A Systematic Review and Meta-Analysis. Archives of psychiatric nursing, 31(4), 420–428.

Pearlstein T. (2008). Perinatal depression:treatment options and dilemmas. Journal of psychiatry & neuroscience: JPN, 33(4), 302–318.

Perales, M., Refoyo, I., Coteron, J., Bacchi, M., & Barakat, R. (2015). Exercise during pregnancy attenuates prenatal depression: a randomized controlled trial. Evaluation & the health professions, 38(1), 59–72.

Pereira, B., Figueiredo, B., Pinto, T. M., & Míguez, M. C. (2020). Effects of Tobacco Consumption and Anxiety or Depression during Pregnancy on Maternal and Neonatal Health. International journal of environmental research and public health, 17(21), 8138.

Pinheiro, K. A., Pinheiro, R. T., Silva, R. A., Coelho, F. M., Quevedo, L.deÁ., Godoy, R. V.,…..Oses, J. P. (2011). Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. Infant behavior & development, 34(2), 371–373.

Rafferty J, Mattson G, Earls MF, Yogman MW; Commıttee On Psychosocıal Aspects Of Chıld And Famıly Health. Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice. Pediatrics. 2019 Jan;143(1):e20183260. doi: 10.1542/peds.2018-3260.

Robertson, E., Grace, S., Wallington, T., & Stewart, D. E. (2004). Antenatal risk factors for postpartum depression: a synthesis of recent literature. General hospital psychiatry, 26(4), 289–295.

Roca, A., Imaz, M. L., Torres, A., Plaza, A., Subirà, S., Valdés, M., Martin-Santos, R., & Garcia-Esteve, L. (2013). Unplanned pregnancy and discontinuation of SSRIs in pregnant women with previously treated affective disorder. Journal of affective disorders, 150(3), 807–813.

Rossi, N. M., & Radney, L. (2022). Diagnosis and Management of Perinatal Depression. Nursing for women's health, 26(4), 318–330.

Sanfilippo, K. R. M., Stewart, L., & Glover, V. (2021). How music may support perinatal mental health: an overview. Archives of women's mental health, 24(5), 831–839.

Satyapriya, M., Nagendra, H. R., Nagarathna, R., & Padmalatha, V. (2009). Effect of integrated yoga on stress and heart rate variability in pregnant women. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 104(3), 218–222.

Skurtveit, S., Selmer, R., Roth, C., Hernandez-Diaz, S., & Handal, M. (2014). Prenatal exposure to antidepressants and language competence at age three: results from a large population-based pregnancy cohort in Norway. BJOG: an international journal of obstetrics and gynaecology, 121(13), 1621–1631.

Sloan, G., Hobson, J., Leighton, J., McFarlane, B., & Law, R. (2009). An overview and history of interpersonal psychotherapy. Nursing standard (Royal College of Nursing (Great Britain) : 1987), 23(26), 44–49.

Slomian, J., Honvo, G., Emonts, P., Reginster, J. Y., & Bruyère, O. (2019). Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes. Women's health (London, England), 15, 1745506519844044.

Smedberg, J., Lupattelli, A., Mårdby, A. C., Øverland, S., & Nordeng, H. (2015). The relationship between maternal depression and smoking cessation during pregnancy--a cross-sectional study of pregnant women from 15 European countries. Archives of women's mental health, 18(1), 73–84.

Sockol L. E. (2015). A systematic review of the efficacy of cognitive behavioral therapy for treating and preventing perinatal depression. Journal of affective disorders, 177, 7–21.

Sockol, L. E., Epperson, C. N., & Barber, J. P. (2011). A meta-analysis of treatments for perinatal depression. Clinical psychology review, 31(5), 839–849.

Sockol, L. E., Epperson, C. N., & Barber, J. P. (2013). Preventing postpartum depression: a meta-analytic review. Clinical psychology review, 33(8), 1205–1217.

Stein, A., Pearson, R. M., Goodman, S. H., Rapa, E., Rahman, A., McCallum, M.,….Pariante, C. M. (2014). Effects of perinatal mental disorders on the fetus and child. Lancet (London, England), 384(9956), 1800–1819.

Stuart, S., & Koleva, H. (2014). Psychological treatments for perinatal depression. Best practice & research. Clinical obstetrics & gynaecology, 28(1), 61–70.

Stuart, S., & Koleva, H. (2014). Psychological treatments for perinatal depression. Best practice & research. Clinical obstetrics & gynaecology, 28(1), 61–70.

Sujan, A. C., Rickert, M. E., Öberg, A. S., Quinn, P. D., Hernández-Díaz, S., Almqvist, C., Lichtenstein, P., Larsson, H., & D'Onofrio, B. M. (2017). Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring. JAMA, 317(15), 1553–1562.

Thomas R. B. (2019). A Pilot Study of Partner Chair Massage Effects on Perinatal Mood, Anxiety, and Pain. International journal of therapeutic massage & bodywork, 12(2), 3–11.

Truijens, S. E. M., Spek, V., van Son, M. J. M., Guid Oei, S., & Pop, V. J. M. (2017). Different patterns of depressive symptoms during pregnancy. Archives of women's mental health, 20(4), 539–546.

Wang, T. H., Tzeng, Y. L., Teng, Y. K., Pai, L. W., & Yeh, T. P. (2022). Evaluation of psychological training for nurses and midwives to optimise care for women with perinatal depression: a systematic review and meta-analysis. Midwifery, 104, 103160.

Wang, Y., Wang, X., Liu, F., Jiang, X., Xiao, Y., Dong, X., Kong, X., Yang, X., Tian, D., & Qu, Z. (2016). Negative Life Events and Antenatal Depression among Pregnant Women in Rural China: The Role of Negative Automatic Thoughts. PloS one, 11(12), e0167597.

Woody, C. A., Ferrari, A. J., Siskind, D. J., Whiteford, H. A., & Harris, M. G. (2017). A systematic review and meta-regression of the prevalence and incidence of perinatal depression. Journal of affective disorders, 219, 86–92.

World Health Organization (2008). U.N.P. Fund (Ed.), MaternalMental Health and Child Survival, Health and Development in ResourceConstrained Settings: Essential for Achieving the Millennium Development Goals, World Health Organization, Geneva, Switzerland

Yang, K., Wu, J., & Chen, X. (2022). Risk factors of perinatal depression in women: a systematic review and meta-analysis. BMC psychiatry, 22(1), 63.

Yasuma, N., Narita, Z., Sasaki, N., Obikane, E., Sekiya, J., Inagawa, T.,……Nishi, D. (2019). Psychological intervention for universal prevention of antenatal and postnatal depression among pregnant women: protocol for a systematic review and meta-analysis. Systematic reviews, 8(1), 297.

Zhang, T. N., Gao, S. Y., Shen, Z. Q., Li, D., Liu, C. X., Lv, H. C., Zhang, Y., Gong, T. T., Xu, X., Ji, C., & Wu, Q. J. (2017). Use of selective serotonin-reuptake inhibitors in the first trimester and risk of cardiovascular-related malformations: a meta-analysis of cohort studies. Scientific reports, 7, 43085.

Zhao, X., Liu, Q., Cao, S., Pang, J., Zhang, H., Feng, T., Deng, Y., Yao, J., & Li, H. (2018). A meta-analysis of selective serotonin reuptake inhibitors (SSRIs) use during prenatal depression and risk of low birth weight and small for gestational age. Journal of affective disorders, 241, 563–570.

Zhu, Y., Wang, R., Tang, X., Li, Q., Xu, G., & Zhang, A. (2021). The effect of music, massage, yoga and exercise on antenatal depression: A meta-analysis. Journal of affective disorders, 292, 592–602.



How to Cite

KARAKAYALI AY , Çiğdem, & ÖZÇALKAP , N. . (2022). Pharmacological, Nonpharmacological and Psychological Therapy Approaches in Management of Perinatal Depression. WORLD WOMEN STUDIES JOURNAL, 7(1), 16–28.




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