All Aspects of Gluten-Free Diet and Its Use in Children

Authors

  • Sabiha Zeynep AYDENK KÖSEOĞLU
  • Şüheda Hilal GÜVEN İstanbul Sabahattin Zaim Üniversitesi

DOI:

https://doi.org/10.5281/zenodo.8154669

Keywords:

Gluten-free diet, Celiac disease, Nutrition in children, Gluten-free diet in diseases

Abstract

Gluten-free diet is a nutrition model in which gluten-containing products such as wheat, oat, barley, or rye and foods made from these products are not consumed. While it is used as an essential treatment in diseases such as celiac disease, non-celiac gluten/wheat sensitivity, and wheat allergy, it is also used as a nutritional therapy in some inflammatory bowel diseases, type 1 diabetes, neurological disorders, autism, dermatitis, irritable bowel syndrome, rheumatoid arthritis, cardiovascular diseases. Considering that gluten has adverse effects on health, the gluten-free nutrition model is applied at a rate of up to 30% in healthy people. While there is a decrease in the intake of fiber, iron, vitamin B1, and folic acid in the gluten-free nutrition model, the fat and calorie content of the products may increase. As a result of the consumption of gluten-free products, changes may occur in the colon, which may negatively affect the activity of bifidobacteria and cause problems in the immune response. Based on previous studies, this review evaluated the effects of using the gluten-free nutrition model in children by considering current sources.

References

Aljada, B., Zohni, A., & El-Matary, W. (2021). The gluten-free diet for celiac disease and beyond. Nutrients, 13(11), 3993.

Aktitiz, S., Yalçın, E., & Göktaş, Z. (2019). Otizm Spektrum Bozuklukları Tedavisinde Beslenme Yaklaşımları. Sağlık Akademisi Kastamonu, 4(2), 127-143.

Akhondi H, Ross AB. (2022). Gluten Associated Medical Problems. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing

Amirikian, K., Sansotta, N., Guandalini, S., & Jericho, H. (2019). Effects of the gluten-free diet on body mass indexes in pediatric celiac patients. Journal of Pediatric Gastroenterology and Nutrition, 68(3), 360-363.

Anania, C., Pacifico, L., Olivero, F., Perla, F. M., & Chiesa, C. (2017). Cardiometabolic risk factors in children with celiac disease on a gluten-free diet. World Journal of Clinical Pediatrics, 6(3), 143.

Antiga E, Verdelli A, Calabro A, Fabbri P, Caproni M. (2013). Clinical and immunopathological features of 159 patients with dermatitis herpetiformis: an Italian experience. Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia.148:163–9.

Antiga, E., Maglie, R., Quintarelli, L., Verdelli, A., Bonciani, D., Bonciolini, V., & Caproni, M. (2019). Dermatitis herpetiformis: novel perspectives. Frontiers in immunology, 10, 1290.

Aydoğdu, S., & Tümgör, G. (2005). Çölyak hastalığı. Güncel Pediatri, 3(1), 47-53.

Babio, N., Alcázar, M., Castillejo, G., Recasens, M., Martínez-Cerezo, F., Gutiérrez-Pensado, V., ... & Salas-Salvadó, J. (2017). Patients with celiac disease reported higher consumption of added sugar and total fat than healthy individuals. Journal of pediatric gastroenterology and nutrition. 64(1), 63-69

Biesiekierski, J. R., Peters, S. L., Newnham, E. D., Rosella, O., Muir, J. G., & Gibson, P. R. (2013). No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology, 145(2), 320-328.

Cecilio L.A., Bonatto M.W. (2015).The Prevalence Of Hla Dq2 And Dq8 In Patients With Celiac Disease, In Family and in General Population. Arquivos Brasileiros de Cirurgia Digestiva. 28:183–185. doi: 10.1590/S0102-67202015000300009.

Cornicelli, M., Saba, M., Machello, N., Silano, M., & Neuhold, S. (2018). Nutritional composition of gluten-free food versus regular food sold in the Italian market. Digestive and Liver Disease, 50(12), 1305-1308.

Drabińska, N., Jarocka-Cyrta, E., Ratcliffe, N. M., & Krupa-Kozak, U. (2019). The profile of urinary headspace volatile organic compounds after 12-week intake of oligofructose-enriched inulin by children and adolescents with celiac disease on a gluten-free diet: Results of a pilot, randomized, placebo-controlled clinical trial. Molecules, 24(7), 1341.

El Khoury, D., Balfour-Ducharme, S., & Joye, I. J. (2018). A review on the gluten-free diet: Technological and nutritional challenges. Nutrients, 10(10), 1410.

Elli, L., Branchi, F., Tomba, C., Villalta, D., Norsa, L., Ferretti, F., ... & Bardella, M. T. (2015). Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity. World journal of gastroenterology: WJG, 21(23), 7110.

Ertaş-Öztürk, Y., & Karabudak, E. (2019). Çocuk Çölyak Hastalarında Glutensiz Diyet ve Mikrobiyota Odaklı Tedavilerin İntestinal Mikrobiyotaya Etkisi. Beslenme ve Diyet Dergisi, 47(2), 93-98.

Gaesser G.A., Angadi S.S. (2012). Gluten-free diet: Imprudent dietary advice for the general population?. Journal of the Academy of Nutrition and Dietetics. 112:1330–1333. doi: 10.1016/j.jand.2012.06.009.

Ghalichi, F., Ghaemmaghami, J., Malek, A. ve Ostadrahimi, A. (2016). Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial. World journal of pediatrics : WJP.12(4), 436-442. doi:10.1007/s12519-016-0040-z

Gaillard, L.A. (2016). Navigating gluten-related health disorders and Nutritional considerations of gluten-free diets. North Carolina Medical Journal, 77(3), 180-182

Garganta M.D., Bremer A.A. (2014). Clinical Dilemmas in Evaluating the Short Child. Pediatri. Annals. 43:321–327. doi: 10.3928/00904481-20140723-11.

Goh, V. L., Estrada, D. E., Lerer, T., Balarezo, F., & Sylvester, F. A. (2010). Effect of gluten-free diet on growth and glycemic control in children with type 1 diabetes and asymptomatic celiac disease. Journal of pediatric endocrinology & metabolism : JPEM. 2010 Nov;23(11):1169-73.

Gürsoy, G., & Öztürk, S. (2019). Otizm Spektrum Bozukluklarında Beslenme Yaklaşımı. Aydın Sağlık Dergisi, 5(2), 111-119.

Håkansson, Å., Andrén Aronsson, C., Brundin, C., Oscarsson, E., Molin, G., & Agardh, D. (2019). Effects of Lactobacillus plantarum and Lactobacillus paracasei on the peripheral immune response in children with celiac disease autoimmunity: a randomized, double-blind, placebo-controlled clinical trial. Nutrients, 11(8), 1925.

Igbinedion, S.O. Ansari, J., Vasikaran, A., Gavins, F.N., Jordan, P. Boktor, M., Alexander, J.S. (2017). Non-celiac gluten sensitivity: All wheat attack is not celiac. World Journal of Gastroenterology, 23(40), 7201-7210.

Karakula-Juchnowicz, H., Rog, J., Juchnowicz, D., Łoniewski, I., Skonieczna-Żydecka, K., Krukow, P., ... & Kaczmarczyk, M. (2019). The study evaluating the effect of probiotic supplementation on the mental status, inflammation, and intestinal barrier in major depressive disorder patients using gluten-free or gluten-containing diet (SANGUT study): A 12-week, randomized, double-blind, and placebo-controlled clinical study protocol. Nutrition journal, 18(1), 1-13.

Kreutz, J. M., Adriaanse, M. P., van der Ploeg, E., & Vreugdenhil, A. C. (2020). Narrative review: nutrient deficiencies in adults and children with treated and untreated celiac disease. Nutrients, 12(2), 500.

Koike Y., Yanagida N., Sato S., Asaumi T., Ogura K., Ohtani K., Imai T., Ebisawa M. (2018). Predictors of Persistent Wheat Allergy in Children: A Retrospective Cohort Study. International archives of allergy and immunology. 176:249–254. doi: 10.1159/000489337

Kutlu, T. (2019). Glutensiz diyet: gerçekten her zaman yararlı mı?. Türk Pediatri Arşivi, 54(2), 73-75.

Lemley KV, Faul C., Schramm K. (2016). Yönetilmesi zor nefrotik sendromlu çocuklarda glutensiz diyetin etkisi. Pediatri. 138 (1) doi: 10.1542/peds.2015-4528. bkz: e20154528.

Leon, J., Pérez-Sáez, M. J., Uffing, A., Murakami, N., Watanabe, A., Cureton, P., ... & Riella, L. V. (2018). Effect of combined gluten-free, dairy-free diet in children with steroid-resistant nephrotic syndrome: An open pilot trial. Kidney international reports, 3(4), 851-860.

Lerner, B. A., Green, P. H., & Lebwohl, B. (2019). Going Against the Grains: Gluten-Free Diets in Patients Without Celiac Disease—Worthwhile or Not?. Digestive diseases and sciences, 64(7), 1740-1747.

Makharia, G. K., Singh, P., Catassi, C., Sanders, D. S., Leffler, D., Ali, R. A. R., & Bai, J. C. (2022). The global burden of coeliac disease: opportunities and challenges. Nature Reviews Gastroenterology & Hepatology, 1-15.

Mariani P., Viti M.G., Montuori M., La V.A., Cipolletta E., Calvani L., Bonamico M. (1998). The gluten-free diet: A nutritional risk factor for adolescents with celiac disease?. Journal of pediatric gastroenterology and nutrition. 27:519–523. doi: 10.1097/00005176-199811000-00004.

Melini, V., & Melini, F. (2019). Gluten-free diet: Gaps and needs for a healthier diet. Nutrients, 11(1), 170.

Mercan, S., & Özel, H. G. (2019). Çocukluk Çağı Kronik Hastalıklarında Tıbbi Beslenme Tedavisi Bağırsak Mikrobiyotasını Etkiler mi?. Beslenme ve Diyet Dergisi, 47(3), 67-75., as cited in ; Di Cagno R, Rizzello CG, Gagliardi F, Ricciuti P, Ndagijimana M, Francavilla R, et al. Different fecal microbiotas and volatile organic compounds in treated and untreated children with celiac disease. Applied and environmental microbiology. 2009;75(12):3963-71

Molina-Infante J, Carroccio A. (2017). Suspected nonceliac gluten sensitivity confirmed in few patients after gluten challenge in double-blind, placebo-controlled trials. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 15:339–348.

Nestares, T., Martin-Masot, R., Labella, A., Aparicio, V. A., Flor-Alemany, M., Lopez-Frias, M., Maldonado, J. (2020). Is a Gluten-Free Diet Enough to Maintain Correct Micronutrients Status in Young Patients with Celiac Disease? Nutrients, 12 (3), 844. doi:10.3390/nu12030844

Nunes-Silva, J. G., Nunes, V. S., Schwartz, R. P., Mlss Trecco, S., Evazian, D., Correa-Giannella, M. L., ... & Queiroz, M. S. (2017). Impact of type 1 diabetes mellitus and celiac disease on nutrition and quality of life. Nutrition & diabetes, 7(1), e239-e239.

Paduano, D., Cingolani, A., Tanda, E., & Usai, P. (2019). Effect of three diets (low-FODMAP, gluten-free and balanced) on irritable bowel syndrome symptoms and health-related quality of life. Nutrients, 11(7), 1566.

Pérez-Sáez, M. J., Uffing, A., Leon, J., Murakami, N., Watanabe, A., Borges, T. J., ... & Riella, L. V. (2021). Immunological impact of a gluten-free dairy-free diet in children with kidney disease: a feasibility study. Frontiers in immunology, 12, 1873.

Popov, J., Baldawi, M., Mbuagbaw, L., Gould, M., Mileski, H., Brill, H., & Pai, N. (2018). Iron Status in Pediatric Celiac Disease: A Retrospective Chart Review. Journal of Pediatric Gastroenterology and Nutrition, 66(4), 651-653.

Punshon, T., Jackson, B.P. (2018). Essential micronutrient and toxic trace element concentrations in gluten containing and gluten-free foods. Food Chemistry, 252(30), 258-264.

Reilly NR, Aguilar K, Hassid BG, Cheng J, Defelice AR, Kazlow P, Bhagat G, Green PH. (2011). Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. Journal of pediatric gastroenterology and nutrition. 53:528–531.

Ricci, G., Andreozzi, L., Cipriani, F., Giannetti, A., Gallucci, M., & Caffarelli, C. (2019). Wheat allergy in children: a comprehensive update. Medicina, 55(7), 400.

Rostami, K., Bold, J., Parr, A., & Johnson, M. W. (2017). Gluten-free diet indications, safety, quality, labels, and challenges. Nutrients, 9(8), 846.

Serin, Y., & Akbulut, G. (2017). Çölyak hastalığı ve glutensiz diyet tedavisine güncel yaklaşım. Journal Of The Turkısh Socıety Of Intensıve Care-Turk Yogun Bakm Dernegı Dergısı, 2(3).192-200.

Söderström, H., Cervin, M., Dereke, J., Hillman, M., Tiberg, I., Norström, F., & Carlsson, A. (2022). Does a gluten-free diet lead to better glycemic control in children with type 1 diabetes? Results from a feasibility study and recommendations for future trials. Contemporary Clinical Trials Communications, 26, 100893.

Stevens L., Rashid M. (2008). Gluten-Free and Regular Foods: A Cost Comparison. Can. J. Diet. Pr. Res. 69:147–150. doi: 10.3148/69.3.2008.147.

Suárez-González, M., Bousoño-García, C., Jiménez-Treviño, S., & Díaz-Martín, J. J. (2021). Gluten-Free Diet: Nutritional Strategies to Improve Eating Habits in Children with Celiac Disease: A Prospective, Single-arm Intervention Study. Nutrients, 13(4), 1108.

Sue, A., Dehlsen, K., & Ooi, C. Y. (2018). Paediatric patients with coeliac disease on a gluten-free diet: nutritional adequacy and macro-and micronutrient imbalances. Current gastroenterology reports, 20(1), 1-12.

Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, Crane J, Camargo CA. (2012). Coeliac disease and gluten avoidance in New Zealand children. Archives of Disease in Childhood. 97:12–16.

Tanpowpong P, Broder-Fingert S, Katz AJ, Camargo CA. (2012). Predictors of gluten avoidance and implementation of a gluten-free diet in children and adolescents without confirmed celiac disease. The Journal of Pediatrics. 161:471–475.

Tavakkoli A, Lewis SK, Tennyson CA, Lebwohl B, Green PH. (2014). Characteristics of patients who avoid wheat and/or gluten in the absence of Celiac disease. Digestive diseases and sciences. 59:1255–1261.

Tortora R., Capone P., De Stefano G., Imperatore N., Gerbino N., Donetto S., Monaco V., Capooraso N., Rispo A. (2015). Metabolic syndrome in patients with coeliac disease on a gluten-free diet. Alimentary pharmacology & therapeutics. 41:352–359. doi: 10.1111/apt.13062.

Tovoli F., Masi C., Guidetti E., Negrini G., Paterini P., Bolondi L. (2013). Clinical and diagnostic aspects of gluten related disorders. World journal of clinical cases. 275–284. doi: 10.12998/wjcc.v3.i3.275.

Tunçer, E., & Ayhan, N. Y. (2021). Çölyak Hastalığında Mikro Besin Ögesi Eksiklikleri ve Beslenme Önerileri. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, 3(1), 29-38.

Ulusoy, H. G., & Rakıcıoğlu, N. (2019). Glutensiz diyetin sağlık üzerine etkileri. Beslenme ve Diyet Dergisi, 47(2), 87-92.

Uy, N., Graf, L., Lemley, K. V., & Kaskel, F. (2015). Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatric research, 77(1), 252-255.

Ülger, T. G., Altun, Ç., & Çakıroğlu, F. P. (2020). Bilinen Terapötik Etkinliğinin Dışında Farklı Hastalıklara Yönelik Glutensiz Diyet Uygulamaları. Ankara Sağlık Bilimleri Dergisi, 9(2), 112-123.

Valletta E., Fornaro M., Cipolli M., Conte S., Bissolo F., Danchielli C. Celiac disease and obesity: Need for nutritional follow-up after diagnosis. European journal of clinical nutrition. 2010;64:1371–1372. doi: 10.1038/ejcn.2010.161.

Van Rijn J.C.W., Grote F.K., Oostdijk W., Wit J.M. (2004). Short stature and the probability of coeliac disease, in the absence of gastrointestinal symptoms. Archives of disease in childhood. 89:882–883. doi: 10.1136/adc.2004.057851.

Vazquez-Roque MI, Camilleri M, Smyrk T, et al. (2013). A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 144:903–911. e3.

Yıldırım, D. (2019). Çölyak hastalığı olan çocuklarda beslenme durumunun değerlendirilmesi. (Hacettepe Üniversitesi , Master's thesis, Sağlık Bilimleri Enstitüsü).

Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Madsen C, Summers C, Sodergren E, Dahlstrom J, Lindner T, Sigurdardottir ST, et al. (2008). The prevalence of plant food allergies: a systematic review. The Journal of allergy and clinical immunology. 121:1210–1218.e4.

Downloads

Published

2023-07-17

How to Cite

AYDENK KÖSEOĞLU , S. Z. ., & GÜVEN , Şüheda H. . (2023). All Aspects of Gluten-Free Diet and Its Use in Children. WORLD WOMEN STUDIES JOURNAL, 8(1), 69–79. https://doi.org/10.5281/zenodo.8154669

Issue

Section

Articles